Bestseller

TB-500

10mg/vial —

$47.31

Select Size

Quantity

99.2%

Purity

Sizes

In Stock

Reviews (2) Overview Key Findings Published Studies (5) Storage & Safety

5.0

Based on 2 reviews

5 ★

4 ★

3 ★

2 ★

1 ★

Nicole R. ↻ Repeat Customer

12 days ago

Third order from this site. Consistent quality every time.

Ryan K. ✓ Verified Buyer

25 days ago

Packaging was discreet and arrived faster than expected. No issues at all.

Mechanism of Action

TB-500 (Thymosin Beta-4) is a 43-amino acid peptide that sequesters G-actin monomers to regulate actin polymerization, promoting cell migration and proliferation. It activates integrin-linked kinase (ILK) and Akt phosphorylation for cell survival signaling, reduces inflammation via NF-kB pathway modulation, and promotes blood vessel formation.

1

Accelerated dermal wound closure by 42-61% over controls with reduced scar formation
2

Enhanced cardiac repair post-MI by activating ILK/Akt and stimulating endogenous cardiac progenitors
3

First molecule to initiate simultaneous myocardial and vascular regeneration after systemic administration
4

Demonstrated anti-inflammatory effects by downregulating TNF-alpha and IL-1 beta
5

Phase II clinical trials showed safety and efficacy in pressure ulcers and epidermolysis bullosa

Thymosin beta-4 accelerates wound healing PMID: 10469335

Malinda KM, Sidhu GS, et al. — Journal of Investigative Dermatology (1999)

TB-4 accelerated dermal wound closure by 42-61%, increased wound contraction, enhanced collagen deposition and angiogenesis

Thymosin beta-4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair PMID: 15565145

Bock-Marquette I, Saxena A, et al. — Nature (2004)

Demonstrated cardioprotective role through ILK activation and Akt phosphorylation

Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization PMID: 17108969

Smart N, Risebro CA, et al. — Nature (2007)

TB-4 reactivated adult epicardium and induced cardiac progenitor mobilization for simultaneous myocardial and vascular regeneration

Thymosin beta-4 promotes angiogenesis, wound healing, and hair follicle development PMID: 15037013

Philp D, Goldstein AL, Kleinman HK — Mechanisms of Ageing and Development (2004)

Comprehensive demonstration of tissue repair across skin, cornea, heart, with hair follicle stimulation

Thymosin beta-4: a multi-functional regenerative peptide PMID: 22074294

Goldstein AL, Hannappel E, Sosne G, Kleinman HK — Expert Opinion on Biological Therapy (2012)

Review establishing TB-4 as a multifunctional regenerative peptide with clinical trial foundation

Storage

Store lyophilized peptide at -20°C for long-term stability. Reconstituted solution should be stored at 2-8°C and used within 30 days. Avoid repeated freeze-thaw cycles.

Reconstitution

Reconstitute with bacteriostatic water (0.9% benzyl alcohol). Add solvent slowly down the side of the vial. Do not shake; gently swirl until dissolved.

Purity & Testing

Purity verified at ≥99.2% by HPLC. Each lot includes Certificate of Analysis with mass spectrometry confirmation and endotoxin testing.

Research Use Only

This product is intended for laboratory research purposes only. Not for human or animal consumption. Not FDA-approved for therapeutic use. Handle according to institutional biosafety protocols.

Frequently Asked Questions about TB-500

What is TB-500?

TB-500 (Thymosin Beta-4 Fragment) is a research-grade peptide supplied at 10mg/vial with ≥99.20% HPLC-verified purity. Thymosin Beta-4 fragment for tissue regeneration research.

What purity is your TB-500?

Our TB-500 is verified at ≥99.20% purity by High-Performance Liquid Chromatography (HPLC). Each lot includes a Certificate of Analysis with mass spectrometry confirmation and endotoxin testing results.

How should I store TB-500?

Store lyophilized TB-500 at -20°C for optimal long-term stability. After reconstitution with bacteriostatic water, store at 2-8°C and use within 30 days. Avoid repeated freeze-thaw cycles to maintain peptide integrity.

Do you offer bulk discounts on TB-500?

Yes. We offer tiered pricing: 3-vial packs include a 7% discount and 5-vial packs include a 14% discount. All multi-vial options are available on this product page above.

Is TB-500 third-party tested?

Yes. Every batch of TB-500 is independently tested by third-party laboratories using HPLC and mass spectrometry. Certificate of Analysis available upon request. All products are manufactured under ISO-compliant conditions.