RESEARCH USE ONLY: All products are for laboratory research purposes only. Not for human or animal consumption.
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Mechanism of Action
SS-31 (Elamipretide) is a synthetic tetrapeptide that selectively targets mitochondrial cardiolipin on the inner membrane. It stabilizes electron transport chain complexes, prevents cytochrome c peroxidase activity, preserves cristae structure, and optimizes oxidative phosphorylation. SS-31 reduces ROS at the site of production rather than scavenging downstream.
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1
Restored mitochondrial ATP production in aged cardiomyocytes to levels comparable with young cells
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2
Improved skeletal muscle performance and exercise tolerance in aged mice after 8 weeks
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3
Protected renal tubular cells from cisplatin-induced mitochondrial dysfunction
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4
Reversed age-related redox stress in skeletal muscle proteome
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5
TAZPOWER trial showed improved 6-Minute Walk Test and cardiac stroke volume in Barth syndrome
First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics
PMID: 24117165
Szeto HH
— British Journal of Pharmacology (2014)
Comprehensive review of SS-31 mechanism targeting mitochondrial cardiolipin
Mitochondrial-targeted peptide rapidly improves mitochondrial energetics and skeletal muscle function in aged mice
PMID: 23692570
Siegel MP, Kruse SE, et al.
— Aging Cell (2013)
Single SS-31 treatment rapidly improved mitochondrial coupling and maximal ATP production in aged mouse skeletal muscle
Improving mitochondrial function with SS-31 reverses age-related redox stress and improves exercise tolerance in aged mice
PMID: 30597195
Campbell MD, Duan J, et al.
— Free Radical Biology and Medicine (2019)
8 weeks of SS-31 reversed age-related energetic deficits and increased treadmill endurance
The mitochondrial-targeted compound SS-31 re-energizes ischemic mitochondria by interacting with cardiolipin
PMID: 23813215
Birk AV, Liu S, et al.
— Journal of the American Society of Nephrology (2013)
SS-31 re-energized ischemic mitochondria and protected kidney structure through direct cardiolipin interaction
A phase 2/3 randomized clinical trial followed by open-label extension to evaluate efficacy and safety of elamipretide in Barth syndrome
PMID: 33077895
Reid Thompson W, et al.
— Genetics in Medicine (2021)
TAZPOWER trial demonstrated improvements in 6-Minute Walk Test and cardiac function
Storage
Store lyophilized peptide at -20°C for long-term stability. Reconstituted solution should be stored at 2-8°C and used within 30 days. Avoid repeated freeze-thaw cycles.
Reconstitution
Reconstitute with bacteriostatic water (0.9% benzyl alcohol). Add solvent slowly down the side of the vial. Do not shake; gently swirl until dissolved.
Purity & Testing
Purity verified at ≥99.1% by HPLC. Each lot includes Certificate of Analysis with mass spectrometry confirmation and endotoxin testing.
Research Use Only
This product is intended for laboratory research purposes only. Not for human or animal consumption. Not FDA-approved for therapeutic use. Handle according to institutional biosafety protocols.
Frequently Asked Questions about SS-31
What is SS-31?
SS-31 (Elamipretide) is a research-grade peptide supplied at 10mg/vial with ≥99.10% HPLC-verified purity. Mitochondria-targeted peptide for cellular energy research.
What purity is your SS-31?
Our SS-31 is verified at ≥99.10% purity by High-Performance Liquid Chromatography (HPLC). Each lot includes a Certificate of Analysis with mass spectrometry confirmation and endotoxin testing results.
How should I store SS-31?
Store lyophilized SS-31 at -20°C for optimal long-term stability. After reconstitution with bacteriostatic water, store at 2-8°C and use within 30 days. Avoid repeated freeze-thaw cycles to maintain peptide integrity.
Do you offer bulk discounts on SS-31?
Yes. We offer tiered pricing: 3-vial packs include a 7% discount and 5-vial packs include a 14% discount. All multi-vial options are available on this product page above.
Is SS-31 third-party tested?
Yes. Every batch of SS-31 is independently tested by third-party laboratories using HPLC and mass spectrometry. Certificate of Analysis available upon request. All products are manufactured under ISO-compliant conditions.
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