RESEARCH USE ONLY: All products are for laboratory research purposes only. Not for human or animal consumption.
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JP
Jordan P.
✓ Verified Buyer
15 days ago
Melanotan I order came in plain packaging. Everything looked correct.
Mechanism of Action
Melanotan-I (Afamelanotide) is a synthetic linear alpha-MSH analogue that selectively activates MC1R on melanocytes, stimulating eumelanin production through cAMP-PKA-CREB-MITF cascade. FDA-approved (2019) as Scenesse for erythropoietic protoporphyria (EPP).
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FDA-approved for EPP: Significantly increased pain-free sun exposure time
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Long-term observational data (8 years, 115 patients) showed sustained quality of life improvement
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Combination with NB-UVB produced superior repigmentation in vitiligo patients
Langendonk JG, Balwani M, et al.
— New England Journal of Medicine (2015)
Afamelanotide increased pain-free sun exposure and improved quality of life in EPP patients
Long-term observational study of afamelanotide in 115 patients with erythropoietic protoporphyria
PMID: 25494545
Biolcati G, Marchesini E, et al.
— British Journal of Dermatology (2015)
Quality of life scores rose from 31% to 74% with only minor adverse events over 8 years
Mitigating photosensitivity of erythropoietic protoporphyria patients by an agonistic analog of alpha-melanocyte stimulating hormone
PMID: 19656325
Harms JH, Lautenschlager S, et al.
— Photochemistry and Photobiology (2009)
Sunlight tolerance increased up to 24-fold with significant melanin density increase
Storage
Store lyophilized peptide at -20°C for long-term stability. Reconstituted solution should be stored at 2-8°C and used within 30 days. Avoid repeated freeze-thaw cycles.
Reconstitution
Reconstitute with bacteriostatic water (0.9% benzyl alcohol). Add solvent slowly down the side of the vial. Do not shake; gently swirl until dissolved.
Purity & Testing
Purity verified at ≥99.2% by HPLC. Each lot includes Certificate of Analysis with mass spectrometry confirmation and endotoxin testing.
Research Use Only
This product is intended for laboratory research purposes only. Not for human or animal consumption. Not FDA-approved for therapeutic use. Handle according to institutional biosafety protocols.
Frequently Asked Questions about Melanotan-I
What is Melanotan-I?
Melanotan-I (Afamelanotide) is a research-grade peptide supplied at 10mg/vial with ≥99.20% HPLC-verified purity. Alpha-MSH analog for melanogenesis research.
What purity is your Melanotan-I?
Our Melanotan-I is verified at ≥99.20% purity by High-Performance Liquid Chromatography (HPLC). Each lot includes a Certificate of Analysis with mass spectrometry confirmation and endotoxin testing results.
How should I store Melanotan-I?
Store lyophilized Melanotan-I at -20°C for optimal long-term stability. After reconstitution with bacteriostatic water, store at 2-8°C and use within 30 days. Avoid repeated freeze-thaw cycles to maintain peptide integrity.
Do you offer bulk discounts on Melanotan-I?
Yes. We offer tiered pricing: 3-vial packs include a 7% discount and 5-vial packs include a 14% discount. All multi-vial options are available on this product page above.
Is Melanotan-I third-party tested?
Yes. Every batch of Melanotan-I is independently tested by third-party laboratories using HPLC and mass spectrometry. Certificate of Analysis available upon request. All products are manufactured under ISO-compliant conditions.
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