RESEARCH USE ONLY: All products are for laboratory research purposes only. Not for human or animal consumption.
By using this site, you confirm you are 21+ and acknowledge these products are not FDA approved.
Mechanism of Action
PT-141 (Bremelanotide, Vyleesi) selectively activates MC3R and MC4R in the hypothalamus, producing sexual arousal through central dopaminergic pathways rather than peripheral vascular mechanisms. FDA-approved (June 2019) for HSDD in premenopausal women.
-
1
FDA-approved as Vyleesi: First CNS-acting treatment for hypoactive sexual desire disorder
-
2
RECONNECT Phase III: Significant improvement in sexual desire and reduction in distress
-
3
52-week extension showed sustained efficacy with no new safety signals
Bremelanotide for the treatment of hypoactive sexual desire disorder: two randomized phase 3 trials
PMID: 31599840
Kingsberg SA, Clayton AH, et al.
— Obstetrics and Gynecology (2019)
Bremelanotide significantly improved sexual desire and reduced distress (RECONNECT trials)
Long-term safety and efficacy of bremelanotide for hypoactive sexual desire disorder
PMID: 31599847
Simon JA, Kingsberg SA, et al.
— Obstetrics and Gynecology (2019)
52-week extension showed sustained HSDD improvement with no new safety signals
Bremelanotide for female sexual dysfunctions in premenopausal women: a randomized, placebo-controlled dose-finding trial
PMID: 27181790
Clayton AH, Althof SE, et al.
— Women's Health (2016)
Established 1.75mg as optimal dose with significant increases in satisfying sexual events
Dhillon S, Keam SJ
— Drugs (2019)
Regulatory review of development milestones leading to June 2019 FDA approval
Storage
Store lyophilized peptide at -20°C for long-term stability. Reconstituted solution should be stored at 2-8°C and used within 30 days. Avoid repeated freeze-thaw cycles.
Reconstitution
Reconstitute with bacteriostatic water (0.9% benzyl alcohol). Add solvent slowly down the side of the vial. Do not shake; gently swirl until dissolved.
Purity & Testing
Purity verified at ≥99.1% by HPLC. Each lot includes Certificate of Analysis with mass spectrometry confirmation and endotoxin testing.
Research Use Only
This product is intended for laboratory research purposes only. Not for human or animal consumption. Not FDA-approved for therapeutic use. Handle according to institutional biosafety protocols.
Frequently Asked Questions about PT-141
What is PT-141?
PT-141 (Bremelanotide) is a research-grade peptide supplied at 10mg/vial with ≥99.10% HPLC-verified purity. MC-R agonist for sexual function research.
What purity is your PT-141?
Our PT-141 is verified at ≥99.10% purity by High-Performance Liquid Chromatography (HPLC). Each lot includes a Certificate of Analysis with mass spectrometry confirmation and endotoxin testing results.
How should I store PT-141?
Store lyophilized PT-141 at -20°C for optimal long-term stability. After reconstitution with bacteriostatic water, store at 2-8°C and use within 30 days. Avoid repeated freeze-thaw cycles to maintain peptide integrity.
Do you offer bulk discounts on PT-141?
Yes. We offer tiered pricing: 3-vial packs include a 7% discount and 5-vial packs include a 14% discount. All multi-vial options are available on this product page above.
Is PT-141 third-party tested?
Yes. Every batch of PT-141 is independently tested by third-party laboratories using HPLC and mass spectrometry. Certificate of Analysis available upon request. All products are manufactured under ISO-compliant conditions.
Related Melanocortin Biology & Reproductive Science Peptides