RESEARCH USE ONLY: All products are for laboratory research purposes only. Not for human or animal consumption.
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Tyler W.
✓ Verified Buyer
17 days ago
Vial seal was intact and packaging was discreet. Smooth order.
Mechanism of Action
Semax is a synthetic heptapeptide analogue of ACTH(4-10) that enhances BDNF and NGF expression through TrkB receptor signaling, modulates serotonergic and dopaminergic systems, and activates PI3K/Akt neuroprotective cascade. Approved in Russia as a nootropic and neuroprotective agent.
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1
Increased BDNF levels 1.4-fold and TrkB phosphorylation 1.6-fold in hippocampus after single intranasal dose
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2
Enhanced striatal dopamine release and serotonin metabolite levels up to 180%
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3
Prevented enhanced NO generation and restored neurologic function following cerebral ischemia
Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus
PMID: 16996037
Dolotov OV, et al.
— Brain Research (2006)
Single intranasal Semax produced 1.4-fold BDNF increase and 1.6-fold TrkB phosphorylation increase
Semax, an ACTH(4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodents
PMID: 16362768
Eremin KO, Kudrin VS, et al.
— Neurochemical Research (2005)
Enhanced striatal dopamine release and 5-HIAA levels to 180%
Novel synthetic analogue of ACTH 4-10 (Semax) but not glycine prevents the enhanced nitric oxide generation in cerebral cortex of rats with incomplete global ischemia
PMID: 11245825
Bashkatova VG, Koshelev VB, et al.
— Brain Research (2001)
Semax abated NO production rise and restored neurologic function following cerebral ischemia
Semax, an analog of ACTH(4-7), regulates expression of immune response genes during ischemic brain injury in rats
PMID: 28255762
Medvedeva EV, Dmitrieva VG, et al.
— Molecular Genetics and Genomics (2017)
Genome-wide analysis revealed Semax affected immune response and interferon signaling genes during ischemia
Storage
Store lyophilized peptide at -20°C for long-term stability. Reconstituted solution should be stored at 2-8°C and used within 30 days. Avoid repeated freeze-thaw cycles.
Reconstitution
Reconstitute with bacteriostatic water (0.9% benzyl alcohol). Add solvent slowly down the side of the vial. Do not shake; gently swirl until dissolved.
Purity & Testing
Purity verified at ≥99.0% by HPLC. Each lot includes Certificate of Analysis with mass spectrometry confirmation and endotoxin testing.
Research Use Only
This product is intended for laboratory research purposes only. Not for human or animal consumption. Not FDA-approved for therapeutic use. Handle according to institutional biosafety protocols.
Frequently Asked Questions about Semax
What is Semax?
Semax (ACTH(4-7)-PGP) is a research-grade peptide supplied at 30mg/vial with ≥99.00% HPLC-verified purity. Heptapeptide nootropic for cognitive research.
What purity is your Semax?
Our Semax is verified at ≥99.00% purity by High-Performance Liquid Chromatography (HPLC). Each lot includes a Certificate of Analysis with mass spectrometry confirmation and endotoxin testing results.
How should I store Semax?
Store lyophilized Semax at -20°C for optimal long-term stability. After reconstitution with bacteriostatic water, store at 2-8°C and use within 30 days. Avoid repeated freeze-thaw cycles to maintain peptide integrity.
Do you offer bulk discounts on Semax?
Yes. We offer tiered pricing: 3-vial packs include a 7% discount and 5-vial packs include a 14% discount. All multi-vial options are available on this product page above.
Is Semax third-party tested?
Yes. Every batch of Semax is independently tested by third-party laboratories using HPLC and mass spectrometry. Certificate of Analysis available upon request. All products are manufactured under ISO-compliant conditions.
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