RESEARCH USE ONLY: All products are for laboratory research purposes only. Not for human or animal consumption.
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Mechanism of Action
MOTS-c is a 16-amino acid mitochondrial-derived peptide encoded in the 12S rRNA gene — the first known mitochondrial-encoded peptide with hormonal function (mitokine). It activates AMPK signaling, enhances glucose uptake via GLUT4 translocation, and under metabolic stress translocates to the nucleus to regulate gene expression.
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1
Prevented age-dependent insulin resistance and diet-induced obesity through AMPK activation
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2
Improved physical performance in aged mice comparable to young controls
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3
Exercise upregulates circulating MOTS-c in humans, establishing it as an exercise-responsive mitokine
The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance
PMID: 25738459
Lee C, Zeng J, et al.
— Cell Metabolism (2015)
Identified MOTS-c as a novel mitokine that prevents diet-induced obesity and insulin resistance through AMPK
The mitochondrial-encoded peptide MOTS-c translocates to the nucleus to regulate nuclear gene expression in response to metabolic stress
PMID: 29983246
Kim KH, Son JM, et al.
— Cell Metabolism (2018)
MOTS-c translocates to the nucleus in an AMPK-dependent manner during metabolic stress
MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis
PMID: 33473109
Reynolds JC, Lai RW, et al.
— Nature Communications (2021)
Exercise induces endogenous MOTS-c in humans; exogenous MOTS-c enhanced physical capacity in aged mice
The mitochondrial-derived peptide MOTS-c is a regulator of plasma metabolites and enhances insulin sensitivity
PMID: 31293078
Kim SJ, Miller B, et al.
— Physiological Reports (2019)
MOTS-c improved insulin sensitivity and beta-oxidation through metabolite modulation
Storage
Store lyophilized peptide at -20°C for long-term stability. Reconstituted solution should be stored at 2-8°C and used within 30 days. Avoid repeated freeze-thaw cycles.
Reconstitution
Reconstitute with bacteriostatic water (0.9% benzyl alcohol). Add solvent slowly down the side of the vial. Do not shake; gently swirl until dissolved.
Purity & Testing
Purity verified at ≥99.1% by HPLC. Each lot includes Certificate of Analysis with mass spectrometry confirmation and endotoxin testing.
Research Use Only
This product is intended for laboratory research purposes only. Not for human or animal consumption. Not FDA-approved for therapeutic use. Handle according to institutional biosafety protocols.
Frequently Asked Questions about MOTS-C
What is MOTS-C?
MOTS-C (Mitochondrial ORF) is a research-grade peptide supplied at 10mg/vial with ≥99.10% HPLC-verified purity. Mitochondrial-derived peptide for exercise mimetic research.
What purity is your MOTS-C?
Our MOTS-C is verified at ≥99.10% purity by High-Performance Liquid Chromatography (HPLC). Each lot includes a Certificate of Analysis with mass spectrometry confirmation and endotoxin testing results.
How should I store MOTS-C?
Store lyophilized MOTS-C at -20°C for optimal long-term stability. After reconstitution with bacteriostatic water, store at 2-8°C and use within 30 days. Avoid repeated freeze-thaw cycles to maintain peptide integrity.
Do you offer bulk discounts on MOTS-C?
Yes. We offer tiered pricing: 3-vial packs include a 7% discount and 5-vial packs include a 14% discount. All multi-vial options are available on this product page above.
Is MOTS-C third-party tested?
Yes. Every batch of MOTS-C is independently tested by third-party laboratories using HPLC and mass spectrometry. Certificate of Analysis available upon request. All products are manufactured under ISO-compliant conditions.
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