RESEARCH USE ONLY: All products are for laboratory research purposes only. Not for human or animal consumption.
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Mechanism of Action
5-Amino-1MQ is a selective inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme overexpressed in adipose tissue. NNMT inhibition increases intracellular NAD+ availability, enhances SIRT1 activity, promotes fatty acid oxidation, and reduces adipocyte size.
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1
Reduced adipocyte size by ~30% in diet-induced obesity models without affecting food intake
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Reduced body weight gain and total body fat while maintaining lean mass
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Increased whole-body energy expenditure without changes in food intake or activity
Selective and membrane-permeable small molecule inhibitor of nicotinamide N-methyltransferase reverses diet-induced obesity in mice
PMID: 29155147
Neelakantan H, Vance V, et al.
— Biochemical Pharmacology (2018)
5-Amino-1MQ reduced body weight gain, adipocyte size, and total body fat without affecting food intake
Nicotinamide N-methyltransferase: more than a vitamin B3 clearance enzyme
PMID: 28291578
Pissios P
— Trends in Endocrinology and Metabolism (2017)
Review establishing NNMT central role in adiposity and energy metabolism
Structure-activity relationship for small molecule inhibitors of nicotinamide N-methyltransferase
PMID: 28548833
Neelakantan H, Wang HY, et al.
— Journal of Medicinal Chemistry (2017)
Established SAR identifying 5-Amino-1MQ as potent selective NNMT inhibitor with IC50 of 1.2 uM
Storage
Store lyophilized peptide at -20°C for long-term stability. Reconstituted solution should be stored at 2-8°C and used within 30 days. Avoid repeated freeze-thaw cycles.
Reconstitution
Reconstitute with bacteriostatic water (0.9% benzyl alcohol). Add solvent slowly down the side of the vial. Do not shake; gently swirl until dissolved.
Purity & Testing
Purity verified at ≥99.0% by HPLC. Each lot includes Certificate of Analysis with mass spectrometry confirmation and endotoxin testing.
Research Use Only
This product is intended for laboratory research purposes only. Not for human or animal consumption. Not FDA-approved for therapeutic use. Handle according to institutional biosafety protocols.
Frequently Asked Questions about 5-Amino-1MQ
What is 5-Amino-1MQ?
5-Amino-1MQ (NNMT Inhibitor) is a research-grade peptide supplied at 60ct · 50mg with ≥99.00% HPLC-verified purity. NNMT inhibitor capsules for metabolic research.
What purity is your 5-Amino-1MQ?
Our 5-Amino-1MQ is verified at ≥99.00% purity by High-Performance Liquid Chromatography (HPLC). Each lot includes a Certificate of Analysis with mass spectrometry confirmation and endotoxin testing results.
How should I store 5-Amino-1MQ?
Store lyophilized 5-Amino-1MQ at -20°C for optimal long-term stability. After reconstitution with bacteriostatic water, store at 2-8°C and use within 30 days. Avoid repeated freeze-thaw cycles to maintain peptide integrity.
Do you offer bulk discounts on 5-Amino-1MQ?
Yes. We offer tiered pricing: 3-vial packs include a 7% discount and 5-vial packs include a 14% discount. All multi-vial options are available on this product page above.
Is 5-Amino-1MQ third-party tested?
Yes. Every batch of 5-Amino-1MQ is independently tested by third-party laboratories using HPLC and mass spectrometry. Certificate of Analysis available upon request. All products are manufactured under ISO-compliant conditions.
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