RESEARCH USE ONLY: All products are for laboratory research purposes only. Not for human or animal consumption.
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Mechanism of Action
GHK-Cu is a naturally occurring tripeptide-copper complex found in human plasma that declines with age. It stimulates collagen I, III, and elastin synthesis via TGF-beta signaling, activates metalloproteinases for tissue remodeling, and modulates expression of over 4,000 genes. The copper ion serves as a cofactor for lysyl oxidase.
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1
Stimulated collagen synthesis by 70% above baseline in human fibroblast cultures
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2
Gene expression analysis revealed modulation of 4,000+ genes across repair and antioxidant pathways
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3
Accelerated wound closure in diabetic rat models with improved collagen organization
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4
Plasma levels decline from ~200 ng/mL at age 20 to ~80 ng/mL by age 60
GHK peptide as a natural modulator of multiple cellular pathways in skin regeneration
PMID: 26236730
Pickart L, Vasquez-Soltero JM, Margolina A
— BioMed Research International (2015)
Review of GHK-Cu effects on 4,000+ genes relevant to skin biology, tissue repair, and antioxidant defense
Regenerative and protective actions of the GHK-Cu peptide in the light of the new gene data
PMID: 29986520
Pickart L, Margolina A
— International Journal of Molecular Sciences (2018)
Demonstrated wound healing, anti-cancer gene modulation, DNA repair, and anti-pain activities
A therapeutic approach for diabetic wound healing using biotinylated GHK incorporated collagen matrices
PMID: 17049946
Arul V, Kartha R, Jayakumar R
— Life Sciences (2007)
GHK-incorporated collagen scaffolds significantly enhanced wound healing in diabetic rats
Pickart L
— Journal of Biomaterials Science, Polymer Edition (2008)
Review establishing GHK-Cu as a key regulator of tissue remodeling
Storage
Store lyophilized peptide at -20°C for long-term stability. Reconstituted solution should be stored at 2-8°C and used within 30 days. Avoid repeated freeze-thaw cycles.
Reconstitution
Reconstitute with bacteriostatic water (0.9% benzyl alcohol). Add solvent slowly down the side of the vial. Do not shake; gently swirl until dissolved.
Purity & Testing
Purity verified at ≥99.3% by HPLC. Each lot includes Certificate of Analysis with mass spectrometry confirmation and endotoxin testing.
Research Use Only
This product is intended for laboratory research purposes only. Not for human or animal consumption. Not FDA-approved for therapeutic use. Handle according to institutional biosafety protocols.
Frequently Asked Questions about GHK-Cu
What is GHK-Cu?
GHK-Cu (Copper Peptide Complex) is a research-grade peptide supplied at 50mg/vial with ≥99.30% HPLC-verified purity. Copper peptide for skin remodeling and collagen research.
What purity is your GHK-Cu?
Our GHK-Cu is verified at ≥99.30% purity by High-Performance Liquid Chromatography (HPLC). Each lot includes a Certificate of Analysis with mass spectrometry confirmation and endotoxin testing results.
How should I store GHK-Cu?
Store lyophilized GHK-Cu at -20°C for optimal long-term stability. After reconstitution with bacteriostatic water, store at 2-8°C and use within 30 days. Avoid repeated freeze-thaw cycles to maintain peptide integrity.
Do you offer bulk discounts on GHK-Cu?
Yes. We offer tiered pricing: 3-vial packs include a 7% discount and 5-vial packs include a 14% discount. All multi-vial options are available on this product page above.
Is GHK-Cu third-party tested?
Yes. Every batch of GHK-Cu is independently tested by third-party laboratories using HPLC and mass spectrometry. Certificate of Analysis available upon request. All products are manufactured under ISO-compliant conditions.
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