RESEARCH USE ONLY: All products are for laboratory research purposes only. Not for human or animal consumption.
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LM
Lori M.
✓ Verified Buyer
12 days ago
KPV arrived quickly and the vial seal was solid.
Mechanism of Action
KPV (Lys-Pro-Val) is the C-terminal tripeptide of alpha-MSH that retains potent anti-inflammatory activity without melanogenic effects. It inhibits NF-kB nuclear translocation, reduces proinflammatory cytokines, and enters colonocytes via the PepT1 transporter for direct intracellular anti-inflammatory action.
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1
Reduced colonic inflammation by 65% in DSS-induced colitis models
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2
Inhibited NF-kB activation through a melanocortin receptor-independent mechanism
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3
Demonstrated antimicrobial properties against S. aureus and Candida albicans
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4
Oral administration effective due to PepT1 transporter uptake in colonocytes
Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease
PMID: 18092346
Kannengiesser K, Maaser C, et al.
— Inflammatory Bowel Diseases (2008)
KPV significantly ameliorated colitis in both DSS and TNBS models through NF-kB inhibition
PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation
PMID: 18061177
Dalmasso G, Charrier-Hisamuddin L, et al.
— Gastroenterology (2008)
KPV enters colonocytes via PepT1 and exerts intracellular anti-inflammatory effects by inhibiting NF-kB
Alpha-MSH and related tripeptides: biochemistry, antiinflammatory and protective effects
PMID: 18612139
Brzoska T, Luger TA, et al.
— Endocrine Reviews (2008)
Comprehensive review of alpha-MSH-derived peptides including KPV anti-inflammatory signaling
Alpha-MSH related peptides: a new class of anti-inflammatory and immunomodulating drugs
PMID: 17934097
Luger TA, Brzoska T
— Annals of the Rheumatic Diseases (2007)
Demonstrated therapeutic potential of alpha-MSH peptides in inflammatory and autoimmune conditions
Storage
Store lyophilized peptide at -20°C for long-term stability. Reconstituted solution should be stored at 2-8°C and used within 30 days. Avoid repeated freeze-thaw cycles.
Reconstitution
Reconstitute with bacteriostatic water (0.9% benzyl alcohol). Add solvent slowly down the side of the vial. Do not shake; gently swirl until dissolved.
Purity & Testing
Purity verified at ≥99.1% by HPLC. Each lot includes Certificate of Analysis with mass spectrometry confirmation and endotoxin testing.
Research Use Only
This product is intended for laboratory research purposes only. Not for human or animal consumption. Not FDA-approved for therapeutic use. Handle according to institutional biosafety protocols.
Frequently Asked Questions about KPV
What is KPV?
KPV (Alpha-MSH Tripeptide) is a research-grade peptide supplied at 10mg/vial with ≥99.10% HPLC-verified purity. Anti-inflammatory tripeptide for dermatology research.
What purity is your KPV?
Our KPV is verified at ≥99.10% purity by High-Performance Liquid Chromatography (HPLC). Each lot includes a Certificate of Analysis with mass spectrometry confirmation and endotoxin testing results.
How should I store KPV?
Store lyophilized KPV at -20°C for optimal long-term stability. After reconstitution with bacteriostatic water, store at 2-8°C and use within 30 days. Avoid repeated freeze-thaw cycles to maintain peptide integrity.
Do you offer bulk discounts on KPV?
Yes. We offer tiered pricing: 3-vial packs include a 7% discount and 5-vial packs include a 14% discount. All multi-vial options are available on this product page above.
Is KPV third-party tested?
Yes. Every batch of KPV is independently tested by third-party laboratories using HPLC and mass spectrometry. Certificate of Analysis available upon request. All products are manufactured under ISO-compliant conditions.
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