Where to Buy Sermorelin in 2026: Sizes, Purity Reports & Verification

Sermorelin is one of the most searched-for compounds in the GHRH-analogue category and one of the easiest to mislabel: the same 29-residue sequence is sold under at least five names, and a closely related modified sequence differs from it by only about 10 Da. This guide covers what sermorelin is chemically, how Pepta Labs lists it, how to read the purity and identity report before you order, and how to store the vial once it arrives.

What Is Sermorelin?

Sermorelin is a synthetic linear 29-residue peptide amide. Its sequence is residues 1-29 of the 44-residue human GRF sequence, closed with a C-terminal primary amide rather than a free carboxylic acid, and all residues are L-amino acids. The single methionine at position 27 accounts for the one sulfur atom in the formula. Every alias in the table refers to the same molecule: GRF(1-29)-NH2 and GHRH(1-29) are fragment notation, and Groliberin is an older name. CAS 86168-78-7 identifies the free peptide; acetate and trifluoroacetate salts are registered separately, which is why the salt form matters when you compare a vendor listing against a database entry (see the CAS number and molecular weight reference).

How Pepta Labs Lists Sermorelin

Pepta Labs lists sermorelin at 5 mg per vial from $41.60 as a lyophilized powder in a sealed glass vial, in the GHRH analogues category. The product page shows the reported purity by reversed-phase HPLC (RP-HPLC) for the production run we sourced. Identity is confirmed by mass spectrometry on the same report, and the salt form (acetate or trifluoroacetate) is stated there. The full analytical report (COA) is available by email request to support@peptalabs.com before purchase.

Three details about that report are worth knowing in advance. Testing is performed by an independent laboratory commissioned through a cooperative purchasing group, so the client field may name the group or the source rather than Pepta Labs, and supplier-identifying fields are redacted before the report is shared. Pepta Labs does not test in-house. Vials do not carry lot numbers; the report describes the production run rather than an individual vial. Full details are on the Testing and Documentation page.

How to Verify a Sermorelin Listing

What an HPLC/MS report shows

The RP-HPLC section reports purity as the area of the main peak as a percentage of all peaks in the chromatogram, together with the column, mobile phase, gradient, detection wavelength and retention time. A single dominant peak with small, well-separated minor peaks is what a high-purity sermorelin lot looks like. The MS section reports the observed mass, usually from an electrospray spectrum in which the peptide appears as multiply charged ions ([M+3H]3+, [M+4H]4+ and so on) that the instrument software deconvolutes to a neutral mass.

Comparing observed mass to theoretical mass

The number to compare is the deconvoluted neutral mass against the theoretical value. Sermorelin's average molecular weight is 3357.93 Da; PubChem's computed monoisotopic mass is 3355.82 Da. Which value the report should match depends on how the instrument resolves the isotope pattern, so a report may legitimately state either, and agreement within about 1 Da is the normal expectation. An observed mass near 3367.95 Da indicates Modified GRF(1-29) rather than sermorelin, and a mass near 3373.9 Da (M+16) points to oxidation of Met27 to the sulfoxide, a known degradation product of methionine-containing peptides.

What the report does not show

An HPLC/MS report does not measure net peptide content. A lyophilized peptide salt contains counter-ion (acetate or trifluoroacetate) and residual water, so 5 mg of gross powder is not 5 mg of free peptide; the TFA vs acetate guide explains the difference. The report also does not certify sterility, endotoxin, residual solvents or chiral purity unless those tests are listed explicitly. Our COA verification guide walks through each field, and the HPLC vs mass spectrometry guide explains why both methods are needed.

Production-run report vs lot-specific COA

A lot-specific COA ties a document to a lot number printed on the vial. A production-run report, which is what Pepta Labs provides, describes the batch of material that was sourced, with no lot number on the vial itself. Both are useful and they answer different questions. Ask which type a vendor is offering, and check that the compound name, formula and molecular weight on the document match the listing rather than a related sequence.

Storage and Shipping

• Sermorelin ships as a lyophilized powder at ambient temperature; the dry solid tolerates transit without cold packs.
• Refrigerate sealed vials at 2-8 C on arrival; move to -20 C for long-term storage.
• Keep the vial sealed and dry and protect it from light. Moisture uptake by the lyophilized cake and oxidation of Met27 are the two changes most likely to appear on a later chromatogram.
• Free US shipping; most orders ship the next business day. See the peptide storage guide for handling of the sealed vial.

US Regulatory Status

Sermorelin has an approved-drug history in the United States. Drugs@FDA records Geref (sermorelin acetate), application number 020443, held by EMD Serono, originally approved on 26 September 1997 and now listed with a marketing status of Discontinued. As of the date this guide was prepared, sermorelin is not named on the FDA's page listing bulk drug substances placed in Category 2 under the interim compounding policies. The wider framework for research-use peptides, including the Category 2 list and the intended-use distinction, is summarised at Peptide Legal Status 2026 and FDA Category 2 Peptides 2026.

Frequently Asked Questions

Is sermorelin the same as GRF(1-29) or GHRH(1-29)?

Yes. Sermorelin is the INN for the 29-residue amide GRF(1-29)-NH2, also written GHRH(1-29)NH2 or hGHRH(1-29)NH2. All of these names describe one peptide: C149H246N44O42S, 3357.93 Da, CAS 86168-78-7.

Which CAS number should appear on a sermorelin listing?

86168-78-7 identifies the free sermorelin peptide. Salt forms are registered separately, so a listing that gives 86168-78-7 alongside the word acetate is describing the parent peptide and its counter-ion, which is normal practice. The analytical report states the salt form actually supplied.

Does the 5 mg on the label mean 5 mg of peptide?

The label states the gross fill of lyophilized powder. Net peptide content is lower because of counter-ion and water, and it is not measured on a standard HPLC/MS report. See the net peptide content guide.

Can I see the report before ordering?

Yes. Email support@peptalabs.com and the current production-run report for sermorelin will be sent, with supplier-identifying fields redacted.