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Mechanism of Action
Sermorelin (GRF 1-29) is the biologically active N-terminal fragment of endogenous GHRH. It binds pituitary GHRH receptors to trigger cAMP-PKA-mediated GH gene transcription and pulsatile release. Extensive safety data spanning decades.
Key Research Findings
- Approximately doubled 12-hour mean GH concentration in healthy elderly men
- Long-term administration increased lean body mass by 1.26 kg in older adults
- Preserves pituitary GH reserve and feedback sensitivity unlike exogenous GH
Peer-Reviewed Studies (4)
Vittone J, Blackman MR, et al.
Metabolism (1997)
Nightly sermorelin injections doubled 12-hour mean GH concentration in healthy elderly men
Khorram O, Laughlin GA, Yen SSC
Journal of Clinical Endocrinology and Metabolism (1997)
5-month treatment increased lean body mass by 1.26 kg and elevated IGF-1
Walker RF
Clinical Interventions in Aging (2006)
Sermorelin may be superior to exogenous GH because it preserves the natural GH feedback axis
Prakash A, Goa KL
BioDrugs (1999)
Review establishing sermorelin efficacy in increasing height velocity in GH-deficient children
Research Disclaimer: The studies referenced above are from publicly available peer-reviewed literature. Pepta Labs products are sold strictly for research purposes. They are not intended for human consumption, therapeutic use, or as dietary supplements. All information is provided for educational and research reference only.