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Mechanism of Action
Semax is a synthetic heptapeptide analogue of ACTH(4-10) that enhances BDNF and NGF expression through TrkB receptor signaling, modulates serotonergic and dopaminergic systems, and activates PI3K/Akt neuroprotective cascade. Approved in Russia as a nootropic and neuroprotective agent.
Key Research Findings
- Increased BDNF levels 1.4-fold and TrkB phosphorylation 1.6-fold in hippocampus after single intranasal dose
- Enhanced striatal dopamine release and serotonin metabolite levels up to 180%
- Prevented enhanced NO generation and restored neurologic function following cerebral ischemia
Peer-Reviewed Studies (4)
Dolotov OV, et al.
Brain Research (2006)
Single intranasal Semax produced 1.4-fold BDNF increase and 1.6-fold TrkB phosphorylation increase
Eremin KO, Kudrin VS, et al.
Neurochemical Research (2005)
Enhanced striatal dopamine release and 5-HIAA levels to 180%
Bashkatova VG, Koshelev VB, et al.
Brain Research (2001)
Semax abated NO production rise and restored neurologic function following cerebral ischemia
Medvedeva EV, Dmitrieva VG, et al.
Molecular Genetics and Genomics (2017)
Genome-wide analysis revealed Semax affected immune response and interferon signaling genes during ischemia
Research Disclaimer: The studies referenced above are from publicly available peer-reviewed literature. Pepta Labs products are sold strictly for research purposes. They are not intended for human consumption, therapeutic use, or as dietary supplements. All information is provided for educational and research reference only.