RESEARCH USE ONLY: All products are for laboratory research purposes only. Not for human or animal consumption.
By using this site, you confirm you are 21+ and acknowledge these products are not FDA approved.
← Back to Research Library
Mechanism of Action
Melanotan-II is a synthetic cyclic heptapeptide alpha-MSH analogue with broad melanocortin receptor activity (MC1R-MC5R). Beyond melanogenesis via MC1R, MC3R/MC4R activation in the hypothalamus modulates appetite and sexual arousal. ~1000-fold greater potency than native alpha-MSH.
Key Research Findings
- Produced significant visible skin darkening at sub-milligram subcutaneous doses
- Initiated erections in 8 of 10 men with psychogenic ED in double-blind crossover study
- Served as parent compound from which PT-141 (bremelanotide) was developed
Peer-Reviewed Studies (4)
Dorr RT, Lines R, et al.
Life Sciences (1996)
MT-II produced tanning and spontaneous penile erection in first-in-human Phase I study
Wessells H, Fuciarelli K, et al.
Journal of Urology (1998)
MT-II initiated erections in 8 of 10 men with psychogenic ED
Wessells H, Levine N, et al.
Urology (2000)
MT-II initiated erections in men with organic ED risk factors
Wessells H, Hruby VJ, et al.
International Journal of Impotence Research (2000)
MT-II led to erection in 17 of 20 men with increased sexual desire after 68% of doses
Research Disclaimer: The studies referenced above are from publicly available peer-reviewed literature. Pepta Labs products are sold strictly for research purposes. They are not intended for human consumption, therapeutic use, or as dietary supplements. All information is provided for educational and research reference only.